Trospium chloride
Chemical compound / From Wikipedia, the free encyclopedia
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Trospium chloride is a muscarinic antagonist used to treat overactive bladder.[2] It has side effects typical of this class of drugs, namely dry mouth, stomach upset, and constipation; these side effects cause problems with people taking their medicine as directed. However it doesn't cause central nervous system side effects like some other muscarinic antagonists.[3] It is in pregnancy category C and is excreted in breast milk.[4]
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Trade names | Regurin, Sanctura, many generics[1] |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth (tablets, capsules) |
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Protein binding | 50–85% |
Elimination half-life | 20 hours |
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ECHA InfoCard | 100.030.784 |
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Formula | C25H30ClNO3 |
Molar mass | 427.97 g·mol−1 |
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Chemically it is a quaternary ammonium cation which causes it to stay in periphery rather than crossing the blood–brain barrier.[5] It works by causing the smooth muscle in the bladder to relax.[2]
It was patented in 1966 and approved for medical use in 1974.[6] It was first approved in the US in 2004, and an extended release version with once-daily dosing was brought to market in 2007. It became generic in Europe in 2009 and in the US the first extended-release generic was approved in 2012.