UDP-N-acetylglucosamine 2-epimerase
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In enzymology, an UDP-N-acetylglucosamine 2-epimerase[note 1] (EC 5.1.3.14) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-glucosamine UDP-N-acetyl-D-mannosamine
UDP-N-acetylglucosamine 2-epimerase | |||||||||
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Identifiers | |||||||||
EC no. | 5.1.3.14 | ||||||||
CAS no. | 9037-71-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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UDP-N-acetylglucosamine 2-epimerase | |||||||||
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Identifiers | |||||||||
Symbol | Epimerase_2 | ||||||||
Pfam | PF02350 | ||||||||
Pfam clan | CL0113 | ||||||||
InterPro | IPR003331 | ||||||||
SCOP2 | 1f6d / SCOPe / SUPFAM | ||||||||
CDD | cd03786 | ||||||||
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Hence, this enzyme has one substrate, UDP-N-acetyl-D-glucosamine, and one product, UDP-N-acetyl-D-mannosamine.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine 2-epimerase. Other names in common use include UDP-N-acetylglucosamine 2'-epimerase, uridine diphosphoacetylglucosamine 2'-epimerase, uridine diphospho-N-acetylglucosamine 2'-epimerase, and uridine diphosphate-N-acetylglucosamine-2'-epimerase. This enzyme participates in aminosugars metabolism.
In microorganisms this epimerase is involved in the synthesis of the capsule precursor UDP-ManNAcA.[1][2] An inhibitor of the bacterial 2-epimerase, epimerox, has been described. Some of these enzymes are bifunctional. The UDP-N-acetylglucosamine 2-epimerase from rat liver displays both epimerase and kinase activity.[3]