Ulipristal acetate
Chemical compound / From Wikipedia, the free encyclopedia
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Ulipristal acetate, sold under the brand name Ella among others, is a medication used for emergency contraception (birth control) and uterine fibroids.[1][5][6] As emergency contraception it should be used within 120 hours of vaginally penetrating intercourse.[1] For fibroids it may be taken for up to six months.[7] It is taken by mouth.[1]
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Trade names | Ella, EllaOne, Esmya, others |
Other names | CDB-2914; 11β-[4-(Dimethylamino)phenyl]-17α-acetoxy-19-norpregna-4,9-diene-3,20-dione |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth |
Drug class | Selective progesterone receptor modulator[1] |
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Bioavailability | Nearly 100% |
Protein binding | 96.7–99.5% |
Metabolism | Likely CYP3A4 |
Elimination half-life | 32 hours[1] |
Excretion | ca. 90% with feces |
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ECHA InfoCard | 100.207.349 |
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Formula | C30H37NO4 |
Molar mass | 475.629 g·mol−1 |
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Common side effects include headache, nausea, feeling tired, and abdominal pain.[1] It should not be used in women who are already pregnant.[1] It is in the selective progesterone receptor modulator (SPRM) class of medications.[1] It works by preventing the effects of progesterone, therefore preventing ovulation but not affecting fertilization or implantation.[8][9]
Ulipristal acetate was approved for medical use in the United States in 2010.[1] It is on the World Health Organization's List of Essential Medicines.[10][11]