User:Dwong527/sandbox
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Phosphoglycerate kinase (EC 2.7.2.3) (PGK) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP. Like all kinases it is a transferase. PGK is a major enzyme used in glycolysis, in the first ATP-generating step of the glycolytic pathway. In gluconeogenesis, the reaction catalyzed by PGK proceeds in the opposite direction, generating ADP and 1,3-BPG. Not all variants of glycolysis use PGK.
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Phosphoglycerate kinase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.2.3 | ||||||||
CAS no. | 9001-83-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Phosphoglycerate kinase | |||||||||
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Identifiers | |||||||||
Symbol | PGK | ||||||||
Pfam | PF00162 | ||||||||
InterPro | IPR001576 | ||||||||
PROSITE | PDOC00102 | ||||||||
SCOP2 | 3pgk / SCOPe / SUPFAM | ||||||||
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In humans, two isozymes of PGK have been so far identified, PGK1 and PGK2. The isoenzymes have 87-88% identical amino acid sequence identity and though they are structurally and functionally similar, they have different localizations: PGK2, encoded by an autosomal gene, is unique to meiotic and postmeiotic spermatogenic cells, while PGK1, encoded on the X-chromosome, is ubiquitously expressed in all cells.[2]