User:Mr. Ibrahem/Bumetanide
From Wikipedia, the free encyclopedia
Bumetanide, sold under the trade name Bumex among others, is a medication used to treat swelling and high blood pressure.[1] This includes swelling as a result of heart failure, liver failure, or kidney problems.[1] It may work for swelling when other medications have not.[1] For high blood pressure it is not a preferred treatment.[1] It is taken by mouth, or by injection into a vein or muscle.[1] Effects generally begin within an hour and lasts for about six hours.[1]
Clinical data | |
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Trade names | Bumex, Burinex, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684051 |
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Routes of administration | By mouth, intravenous, intramuscular |
Drug class | Loop diuretic[1] |
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Pharmacokinetic data | |
Bioavailability | Almost complete (~80%) |
Protein binding | 97% |
Metabolism | Liver |
Elimination half-life | ~0.8 hours |
Excretion | Kidney |
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Chemical and physical data | |
Formula | C17H20N2O5S |
Molar mass | 364.42 g·mol−1 |
3D model (JSmol) | |
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Common side effects include dizziness, low blood pressure, low blood potassium, muscle cramps, and kidney problems.[1] Other serious side effects may include hearing loss and low blood platelets.[1] People with a sulfa allergy, may also be allergic to bumetanide.[1] Blood tests are recommended regularly for those on treatment.[1] Safety during pregnancy and breastfeeding is unclear.[2] Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys.[3][1]
Bumetanide was patented in 1968 and came into medical use in 1972.[4] It is available as a generic medication.[3] A month supply in the United Kingdom costs the NHS about £1.20 as of 2019.[3] In the United States the wholesale cost of this amount is about US$12.[5] In 2017, it was the 277th most commonly prescribed medication in the United States, with more than one million prescriptions.[6][7]