User:Mr. Ibrahem/Cetrorelix
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Cetrorelix , sold under the brand name Cetrotide, is a medication used in fertility treatment to prevent early ovulation in women getting ovarian stimulation.[2] It is given by injection under the skin.[3]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Cetrotide, others |
Other names | Cetrorelix acetate |
AHFS/Drugs.com | Monograph |
Routes of administration | Subcutaneous injection |
Drug class | GnRH antagonist[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 85% |
Protein binding | 86% |
Elimination half-life | 62.8 hours / 3 mg single dose; 5 hours / 0.25 mg single dose; 20.6 hours / 0.25 mg multiple doses |
Excretion | feces (5% to 10% as unchanged drug and metabolites); urine (2% to 4% as unchanged drug) |
Identifiers | |
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Chemical and physical data | |
Formula | C70H92ClN17O14 |
Molar mass | 1431.06 g·mol−1 |
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Common side effects include ovarian hyperstimulation syndrome, nausea, and headache.[1] Other side effects may include anaphylaxis and liver problems.[1] Use during pregnancy may harm the baby.[1] It is a gonadotropin-releasing hormone (GnRH) blocker.[1]
Cetrorelix was approved for medical use in Europe in 1999 and the United States in 2000.[2][1] In the United Kingdom 250 micrograms costs the NHS about £27 as of 2021.[3] This amount in the United States costs about 250 USD.[4]