User:Mr. Ibrahem/Nefazodone
From Wikipedia, the free encyclopedia
Nefazodone, sold under various brand names, is a medication primarily used to treat major depressive disorder.[1] Other uses include aggressive behavior and panic disorder.[4] It is taken by mouth.[1]
Clinical data | |
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Trade names | Serzone, Dutonin, Nefadar, others |
Other names | BMY-13754-1; MJ-13754-1 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a695005 |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Antidepressant[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 20% (variable)[2] |
Protein binding | 99% (loosely)[2] |
Metabolism | Liver (CYP3A4, CYP2D6)[3] |
Metabolites | • Hydroxynefazodone[2] • mCPPTooltip meta-Chlorophenylpiperazine[2] • p-Hydroxynefazodone[3] • Triazoledione[2] |
Elimination half-life | • Nefazodone: 2–4 hours[2] • Hydroxynefazodone: 1.5–4 hours[2] • Triazoledione: 18 hours[2] • mCPPTooltip meta-Chlorophenylpiperazine: 4–8 hours[2] |
Excretion | Urine: 55% Feces: 20–30% |
Identifiers | |
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Chemical and physical data | |
Formula | C25H32ClN5O2 |
Molar mass | 470.01 g·mol−1 |
3D model (JSmol) | |
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Common side effects include sleepiness, dry mouth, nausea, constipation, blurry vision, and confusion.[1] Other side effects may include liver problems, suicide, bipolar disorder, seizures, and priapism.[1] Safety in pregnancy is unclear.[5] How it works in not entirely clear but may involved effects on 5-HT and norepinephrine within the brain.[2]
Nefazodone was patented in 1982 and approved for medical use in the United States in 1988.[4][6] It is available as a generic medication.[1] In the United States it costs about 260 USD per month as of 2021.[7] It is no longer commonly used due to concerns with liver problems.[4] It was removed from the market in Europe, Canada, and Australia as of 2004.[8]