User:Mr. Ibrahem/Pitolisant
From Wikipedia, the free encyclopedia
Pitolisant, sold under the brand name Wakix among others, is a medication for the treatment of excessive daytime sleepiness in narcolepsy.[1] It is taken by mouth once a day in the morning.[3][4]
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Trade names | Wakix, Ozawade, others |
Other names | Tiprolisant; Ciproxidine; BF2.649 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a619055 |
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Routes of administration | By mouth |
Drug class | Histamine 3 (H3) receptor inhibitor[1] |
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Chemical and physical data | |
Formula | C17H26ClNO |
Molar mass | 295.85 g·mol−1 |
3D model (JSmol) | |
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Common side effects include headache, trouble sleeping, nausea, and anxiety.[3] Other side effects may include QT prolongation.[5] Safety in pregnancy is unclear.[6] It bring about an opposite to usual response at the histamine 3 (H3) receptor.[1] This increases the activity of histamine neurons in the brain, which keeps a person awake.[7][3]
Pitolisant was approved for medical use in the United States in 2019 and Europe in 2021.[5][3] In the United Kingdom it costs the NHS about £310 per month as of 2021.[4] In the United States this amount costs about 6,800 USD.[8]