VGF
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
VGF or VGF nerve growth factor inducible is a secreted protein and neuropeptide precursor that may play a role in regulating energy homeostasis, metabolism[5] and synaptic plasticity.[6] The protein was first discovered in 1985 by Levi et al.[7] in an experiment with PC12 cells and its name is non-acronymic. VGF gene encodes a precursor which is divided by proteolysis to polypeptides of different mass, which have a variety of functions, the best studied of which are the roles of TLQP-21 in the control of appetite and inflammation,[8][9][10][11][12][13][14][15] and TLQP-62 as well as AQEE-30 in regulating depression-like behaviors[16][17][18][19][20] and memory.[21][22] The expression of VGF and VGF-derived peptides is detected in a subset of neurons in the central and peripheral nervous systems and specific populations of endocrine cells in the adenohypophysis, adrenal medulla, gastrointestinal tract, and pancreas.[23] VGF expression is induced by NGF, CREB and BDNF and regulated by neurotrophin-3.[24] Physical exercise significantly increases VGF expression in mice hippocampal tissue and upregulates a neurotrophic signaling cascade thought to underlie the action of antidepressants.[16][25][26][27]
VGF | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | VGF, SCG7, SgVII, VGF nerve growth factor inducible | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602186 MGI: 1343180 HomoloGene: 2536 GeneCards: VGF | ||||||||||||||||||||||||||||||||||||||||||||||||||
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