Vitamin B12 total synthesis
Industrial synthesis of chemical substance / From Wikipedia, the free encyclopedia
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The total synthesis of the complex biomolecule vitamin B12 was accomplished in two different approaches by the collaborating research groups of Robert Burns Woodward at Harvard[1][2][3][4][5] and Albert Eschenmoser at ETH[6][7][8][9][10][11][12] in 1972. The accomplishment required the effort of no less than 91 postdoctoral researchers (Harvard: 77, ETH: 14)[13]: 9-10 [14], and 12 Ph.D. students (at ETH[12]: 1420 ) from 19 different nations over a period of almost 12 years.[5]: 1:14:00-1:14:32,1:15:50-1:19:35 [14]: 17-18 The synthesis project[15] induced and involved a major change of paradigm[16][17]: 37 [18]: 1488 in the field of natural product synthesis.[19][20][21]