Vortioxetine
Serotonin modulator antidepressant / From Wikipedia, the free encyclopedia
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Vortioxetine, sold under the brand names Trintellix and Brintellix among others, is an antidepressant of the serotonin modulator and stimulator (SMS) class.[14][3] Its effectiveness is viewed as similar to that of other antidepressants.[14] It is taken by mouth.[14]
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Pronunciation | /vɔːrtiˈɒksətiːn/ vor-tee-OK-sə-teen |
Trade names | Trintellix, Brintellix, others |
Other names | Lu AA21004, Vortioxetine hydrobromide (JAN JP), Vortioxetine hydrobromide (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a614003 |
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Routes of administration | By mouth |
Drug class | Selective serotonin reuptake inhibitor (SSRI)[3] |
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Bioavailability | 75% (peak at 7–11 hours)[12] |
Protein binding | 98–99%[12][10][13] |
Metabolism | Liver, primarily CYP2D6-mediated oxidation[12] |
Elimination half-life | 66 hours[12] |
Excretion | 59% in urine, 26% in feces[12] |
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ECHA InfoCard | 100.258.748 |
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Formula | C18H22N2S |
Molar mass | 298.45 g·mol−1 |
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Common side effects include nausea, vomiting, constipation, and sexual dysfunction.[14][10] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and SIADH.[14] A withdrawal syndrome may occur if the medication is abruptly stopped or the dose is decreased.[14] Use during pregnancy and breastfeeding is not generally recommended.[15] Vortioxetine's mechanism of action is not entirely understood, but is believed to be related to increasing serotonin levels and possibly interacting with certain receptors for serotonin.[14][16][17]
It was approved for medical use in the United States in 2013.[14][18] In 2020, it was the 243rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.[19][20]