Wolfram syndrome
Human disease / From Wikipedia, the free encyclopedia
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Wolfram syndrome, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare autosomal-recessive genetic disorder that causes childhood-onset diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders including neurodegeneration.[2][3][4]
Quick Facts Other names, Specialty ...
Wolfram syndrome | |
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Other names | Diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome |
Photographic image of the eye showing optic atrophy without retinopathy; from Manaviat et al., 2009[1] | |
Specialty | Medical genetics, neurology |
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It was first described in four siblings in 1938 by Dr. Don J. Wolfram, M.D.[2] The disease affects the central nervous system (especially the brainstem).