Zonisamide
Chemical compound / From Wikipedia, the free encyclopedia
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Zonisamide, sold under the brand name Zonegran among others, is a medication used to treat the symptoms of epilepsy and Parkinson's disease.[5][6] Chemically it is a sulfonamide. It serves as an anticonvulsant used primarily as an adjunctive therapy in adults with Parkinson's disease, partial-onset seizures; infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic and generalized tonic clonic seizure.[7] Despite this it is also sometimes used as a monotherapy for partial-onset seizures.[6][8]
Quick Facts Clinical data, Trade names ...
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Trade names | Zonegran, Zonisade |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603008 |
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Routes of administration | By mouth |
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Bioavailability | ~100%[4] |
Protein binding | 40%[4] |
Metabolism | Liver through CYP3A4[4] |
Elimination half-life | 63 hours in plasma[4] |
Excretion | Kidney (62%); Faeces (3%)[4] |
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ECHA InfoCard | 100.118.526 |
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Formula | C8H8N2O3S |
Molar mass | 212.22 g·mol−1 |
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Melting point | 162 °C (324 °F) |
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In 2020, it was the 276th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[9][10]