Β,N,N-Trimethylphenethylamine

β,N,N-Trimethylphenethylamine, also known as N,N-dimethyl-2-phenylpropan-1-amine (N,N-DMPPA or DMPPA) is a monoamine releasing agent of the phenethylamine family.^[1] It is the N-methyl derivative of phenpromethamine (β,N-methylphenethylamine) and the N,N-dimethyl derivative of β-methylphenethylamine.^[1] The drug is a partial norepinephrine releasing agent, with an EC₅₀Tooltip half-maximal effective concentration of 1,337 nM and an E_maxTooltip maximal efficacy of 67% in rat brain synaptosomes.^[1] Conversely, it was inactive on dopamine, whereas serotonin was not reported.^[1] The drug produces non-significant increases in blood pressure in rodents, but does not affect heart rate or affect locomotor activity.^[1] It may be rapidly metabolized and thereby inactivated.^[1] DMPPA was first described in the scientific literature by at least 2019.^[1]

β,N,N-Trimethylphenethylamine

Clinical data
Other names	N,N-Dimethyl-2-phenylpropan-1-amine; N,N-DMPPA; DMPPA; β,N,N-TMPEA
Identifiers
IUPAC name N,N-dimethyl-2-phenylpropan-1-amine
CAS Number	7560-81-8
PubChem CID	65295
ChemSpider	58784
CompTox Dashboard (EPA)	DTXSID10964341
Chemical and physical data
Formula	C11H17N
Molar mass	163.264 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(CN(C)C)C1=CC=CC=C1
InChI InChI=1S/C11H17N/c1-10(9-12(2)3)11-7-5-4-6-8-11/h4-8,10H,9H2,1-3H3 Key:JFNWQFWYAAPODB-UHFFFAOYSA-N

See also

• β-Methylamphetamine
• Dimethylamphetamine