(S)-3-hydroxyacid-ester dehydrogenase

In enzymology, a (S)-3-hydroxyacid-ester dehydrogenase (EC 1.1.1.280) is an enzyme that catalyzes the chemical reaction

ethyl (S)-3-hydroxyhexanoate + NADP⁺ ${\displaystyle \rightleftharpoons }$ ethyl 3-oxohexanoate + NADPH + H⁺

(S)-3-hydroxyacid-ester dehydrogenase
Identifiers
EC no.	1.1.1.280
CAS no.	114705-03-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are ethyl (S)-3-hydroxyhexanoate and NADP⁺, whereas its 3 products are ethyl 3-oxohexanoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is ethyl-(S)-3-hydroxyhexanoate:NADP⁺ 3-oxidoreductase. This enzyme is also called 3-oxo ester (S)-reductase.