1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

In enzymology, a 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase (EC 1.3.1.68) is an enzyme that catalyzes the chemical reaction

1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 3-methylcatechol + NADH + CO₂

1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
Identifiers
EC no.	1.3.1.68
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate and NAD⁺, whereas its 3 products are 3-methylcatechol, NADH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in toluene and xylene degradation.