16-alpha-hydroxysteroid dehydrogenase

In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction

a 16alpha-hydroxysteroid + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ a 16-oxosteroid + NAD(P)H + H⁺

16-alpha-hydroxysteroid dehydrogenase
Identifiers
EC no.	1.1.1.147
CAS no.	37250-74-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD⁺, and NADP⁺, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)⁺ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.