2′-NH2-MPTP

2′-NH₂-MPTP, also known as 2′-amino-MPTP, is a monoaminergic neurotoxin that was derived from MPTP and is used in scientific research to lesion brain monoaminergic systems in animals.^[1][2] Whereas MPTP is a selective dopaminergic neurotoxin, 2′-NH₂-MPTP is a specific serotonergic and noradrenergic neurotoxin that does not affect dopaminergic neurons.^[1][2] 2′-NH₂-MPTP is transported by the serotonin transporter (SERT) into serotonergic neurons and by the norepinephrine transporter (NET) into noradrenergic neurons, and its serotonergic and noradrenergic neurotoxicity is dependent on this transport by the SERT and NET, respectively.^[3][4][5] 2′-NH₂-MPTP was first described in the scientific literature by 1993.^[1][6]

2′-NH₂-MPTP

Clinical data
Other names	2′-Amino-MPTP
Drug class	Serotonergic and noradrenergic neurotoxin
Identifiers
IUPAC name 2-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)aniline
CAS Number	108114-93-8
PubChem CID	130045
ChemSpider	115097
ChEMBL	ChEMBL1188920
CompTox Dashboard (EPA)	DTXSID00148416
Chemical and physical data
Formula	C12H16N2
Molar mass	188.274 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CCC(=CC1)C2=CC=CC=C2N
InChI InChI=1S/C12H16N2/c1-14-8-6-10(7-9-14)11-4-2-3-5-12(11)13/h2-6H,7-9,13H2,1H3 Key:BRFNXNYQQYJJAQ-UHFFFAOYSA-N

See also

• 2′-CH₃-MPTP