2',3'-cyclic-nucleotide 2'-phosphodiesterase

The enzyme 2′,3′-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) catalyzes the reaction

nucleoside 2′,3′-cyclic phosphate + H₂O ${\displaystyle \rightleftharpoons }$ nucleoside 3′-phosphate

2′,3′-cyclic-nucleotide 2′-phosphodiesterase
Identifiers
EC no.	3.1.4.16
CAS no.	9037-18-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is nucleoside-2′,3′-cyclic-phosphate 3'-nucleotidohydrolase. Other names in common use include ribonucleoside 2′,3′-cyclic phosphate diesterase, 2′,3′-cyclic AMP phosphodiesterase, 2′,3′-cyclic nucleotidase, cyclic 2′,3′-nucleotide 2′-phosphodiesterase, cyclic 2′,3′-nucleotide phosphodiesterase, 2′,3′-cyclic nucleoside monophosphate phosphodiesterase, 2′,3′-cyclic AMP 2′-phosphohydrolase, cyclic phosphodiesterase:3′-nucleotidase, 2′,3′-cyclic nucleotide phosphohydrolase, 2′:3′-cyclic phosphodiesterase, and 2′:3′-cyclic nucleotide phosphodiesterase:3'-nucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism.