2-Bromothiophene

2-Bromothiophene is an organosulfur compound with the formula C₄H₃BrS. It is a colorless liquid. Unlike 3-bromothiophene, the 2-bromo isomer is prepared directly by partial bromination of thiophene. It is a precursor to several drugs, including tipepidine, ticlopidine, and clopidogrel.^[1]

2-Bromothiophene

Names
Preferred IUPAC name 2-Bromothiophene
Other names 2-Thienyl bromide, 2BT
Identifiers
CAS Number	1003-09-4
3D model (JSmol)	Interactive image
ChemSpider	13251
ECHA InfoCard	100.012.454
EC Number	213-699-4
PubChem CID	13851
UNII	GFF929NUW7 Y
CompTox Dashboard (EPA)	DTXSID4061389
InChI InChI=1S/C4H3BrS/c5-4-2-1-3-6-4/h1-3H Key: TUCRZHGAIRVWTI-UHFFFAOYSA-N
SMILES C1=CSC(=C1)Br
Properties
Chemical formula	C4H3BrS
Molar mass	163.03 g·mol−1
Appearance	Colorless liquid
Density	1.684 g/mL
Melting point	−10 °C (14 °F; 263 K)
Boiling point	153.5 °C (308.3 °F; 426.6 K)
Solubility in water	Immiscible
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	N,Xi,Xn,T
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H226, H300, H301, H310, H315, H318, H319, H330
Precautionary statements	P210, P233, P240, P241, P242, P243, P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501
Flash point	56 °C (133 °F; 329 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Safety

The LD50 is low, 200 – 250 mg/kg (oral, rat).^[1]