2-Coumarate reductase

In enzymology, a 2-coumarate reductase or melilotate dehydrogenase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction

3-(2-hydroxyphenyl)propanoate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 2-coumarate + NADH + H⁺

2-coumarate reductase
Identifiers
EC no.	1.3.1.11
CAS no.	37251-10-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD⁺, whereas its 3 products are 2-coumarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism.