2-dehydro-3-deoxy-6-phosphogalactonate aldolase

The enzyme 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.21) catalyzes the chemical reaction

2-dehydro-3-deoxy-D-galactonate 6-phosphate ${\displaystyle \rightleftharpoons }$ pyruvate + D-glyceraldehyde 3-phosphate

2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Identifiers
EC no.	4.1.2.21
CAS no.	9030-99-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming). Other names in common use include 6-phospho-2-keto-3-deoxygalactonate aldolase, phospho-2-keto-3-deoxygalactonate aldolase, 2-keto-3-deoxy-6-phosphogalactonic aldolase, phospho-2-keto-3-deoxygalactonic aldolase, 2-keto-3-deoxy-6-phosphogalactonic acid aldolase, (KDPGal)aldolase, 2-dehydro-3-deoxy-D-galactonate-6-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in galactose metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2V81 and 2V82.