2-hydroxy-3-oxoadipate synthase

In enzymology, a 2-hydroxy-3-oxoadipate synthase (EC 2.2.1.5) is an enzyme that catalyzes the following chemical reaction:

2-oxoglutarate + glyoxylate ${\displaystyle \rightleftharpoons }$ 2-hydroxy-3-oxoadipate + CO₂

2-hydroxy-3-oxoadipate synthase
Identifiers
EC no.	2.2.1.5
CAS no.	9054-72-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are 2-oxoglutarate and glyoxylate, whereas its two products are 2-hydroxy-3-oxoadipate and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.