Isoflavonoid synthase

2-hydroxyisoflavanone synthase (EC 1.14.13.136, CYT93C, IFS, isoflavonoid synthase) is an enzyme with systematic name liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration).^[1][2][3] This enzyme catalyses the following chemical reactions:

liquiritigenin + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ 2,4',7-trihydroxyisoflavanone + H₂O + NADP⁺

Isoflavonoid synthase
Identifiers
EC no.	1.14.13.136
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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and

(2S)-naringenin + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ 2,4',5,7-tetrahydroxyisoflavanone + H₂O + NADP⁺

Isoflavonoid synthase requires cytochrome P450.