2-hydroxymethylglutarate dehydrogenase

In enzymology, a 2-hydroxymethylglutarate dehydrogenase (EC 1.1.1.291) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxymethylglutarate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 2-formylglutarate + NADH + H⁺

2-hydroxymethylglutarate dehydrogenase
Identifiers
EC no.	1.1.1.291
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are (S)-2-hydroxymethylglutarate and NAD⁺, whereas its 3 products are 2-formylglutarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxymethylglutarate:NAD⁺ oxidoreductase. This enzyme is also called HgD.