2-methylisocitrate dehydratase

The enzyme 2-methylisocitrate dehydratase (EC 4.2.1.99) catalyzes the chemical reaction

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate ${\displaystyle \rightleftharpoons }$ (Z)-but-2-ene-1,2,3-tricarboxylate + H₂O

2-methylisocitrate dehydratase
Identifiers
EC no.	4.2.1.99
CAS no.	170780-51-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]. This enzyme is also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.