2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)

2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) (EC 1.14.11.34, ethylene-forming enzyme, EFE) is an enzyme with systematic name L-arginine,2-oxoglutarate:oxygen oxidoreductase (succinate-forming).^[1][2][3] This enzyme catalyses the following chemical reaction

2-oxoglutarate + L-arginine + O₂ ${\displaystyle \rightleftharpoons }$ succinate + CO₂ + guanidine + (S)-1-pyrroline-5-carboxylate + H₂O (overall reaction)

(1a) 2-oxoglutarate + L-arginine + O₂ ${\displaystyle \rightleftharpoons }$ succinate + CO₂ + L-hydroxyarginine

(1b) L-hydroxyarginine ${\displaystyle \rightleftharpoons }$ guanidine + (S)-1-pyrroline-5-carboxylate + H₂O

2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
Identifiers
EC no.	1.14.11.34
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-oxoglutarate/L-arginine monooxygenase/decarboxylase catalyses two cycles of the ethylene-forming reaction.