2-oxopent-4-enoate hydratase

The enzyme 2-oxopent-4-enoate hydratase (EC 4.2.1.80) catalyzes the chemical reaction

4-hydroxy-2-oxopentanoate ${\displaystyle \rightleftharpoons }$ 2-oxopent-4-enoate + H₂O

2-oxopent-4-enoate hydratase
2-Oxopent-4-enoate hydratase homo60mer, E.Coli
Identifiers
EC no.	4.2.1.80
CAS no.	64427-80-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming). Other names in common use include 2-keto-4-pentenoate hydratase, OEH, 2-keto-4-pentenoate (vinylpyruvate)hydratase, and 4-hydroxy-2-oxopentanoate hydro-lyase. This enzyme participates in nine metabolic pathways: phenylalanine metabolism, benzoate degradation via hydroxylation, biphenyl degradation, toluene and xylene degradation, 1,4-dichlorobenzene degradation, fluorene degradation, carbazole degradation, ethylbenzene degradation, and styrene degradation.