2-Phenyl-2-propanol

2-Phenyl-2-propanol is a chemical compound that belongs to the alcohol group. It is a derivative of cumene.

2-Phenyl-2-propanol

Names
IUPAC name 2-Phenyl-2-propanol
Identifiers
CAS Number	617-94-7
3D model (JSmol)	Interactive image
ChEBI	CHEBI:131607
ChEMBL	ChEMBL3185495
ChemSpider	11556
ECHA InfoCard	100.009.582
EC Number	210-539-5
PubChem CID	12053
UNII	JE030BGE05
CompTox Dashboard (EPA)	DTXSID3027247
InChI InChI=1S/C9H12O/c1-9(2,10)8-6-4-3-5-7-8/h3-7,10H,1-2H3 Key: BDCFWIDZNLCTMF-UHFFFAOYSA-N
SMILES CC(C)(C1=CC=CC=C1)O
Properties
Chemical formula	C9H12O
Molar mass	136.19 g/mol
Appearance	White to pale yellow odorless solid[1]
Density	0.973 g/cm3[1]
Melting point	28–32 °C (301–305 K)[1]
Boiling point	202[1] °C (396 °F; 475 K)
Solubility in water	Practically insoluble[2]
Solubility	Soluble in ethanol and benzene[3]
Refractive index (nD)	1.49146 (20 °C)[4]
Hazards
GHS labelling:
Pictograms	[1]
Signal word	Danger
Hazard statements	H302, H315, H319
Precautionary statements	P280, P301+P330+P331, P302+P352, P305+P351+P338, P362[1]
Lethal dose or concentration (LD, LC):
LD50 (median dose)	4300mg/kg (rabbit,transdermal);[1] 1300mg/kg (rat, oral) [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Synthesis

2-Phenyl-2-propanol can be synthesized through Grignard reaction between phenylmagnesium bromide and acetone.^[5][6]

Properties

2-Phenyl-2-propanol is a white to pale-yellow, odorless solid which is combustible yet difficult to ignite and barely dissolves in water.^[1][2]

Applications

2-Phenyl-2-propanol can either be applied in organic syntheses, or be reactants or intermediates in agrochemical, medical, and dyestuff fields.^[2]

2-Phenyl-2-propanol is the main metabolite of cumene, and therefore 2-phenyl-2-propanol can serve as a biomarker of cumene.^[7]

Hazards

According to a report of Federal Institute for Risk Assessment in 2008, there is strong evidence that 2-phenyl-2-propanol may lead to allergic reactions for humans.^[8]