3'-demethylstaurosporine O-methyltransferase

In enzymology, a 3'-demethylstaurosporine O-methyltransferase (EC 2.1.1.139) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3'-demethylstaurosporine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + staurosporine

3'-demethylstaurosporine O-methyltransferase
Identifiers
EC no.	2.1.1.139
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-demethylstaurosporine, whereas its two products are S-adenosylhomocysteine and staurosporine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase. Other names in common use include 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, and staurosporine synthase.