3-dehydro-L-gulonate-6-phosphate decarboxylase

The enzyme 3-dehydro-L-gulonate-6-phosphate decarboxylase (EC 4.1.1.85) catalyzes the chemical reaction

3-dehydro-L-gulonate 6-phosphate + H⁺ ${\displaystyle \rightleftharpoons }$ L-xylulose 5-phosphate + CO₂

3-dehydro-L-gulonate-6-phosphate decarboxylase
Identifiers
EC no.	4.1.1.85
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming). Other names in common use include 3-keto-L-gulonate 6-phosphate decarboxylase, UlaD, SgaH, SgbH, KGPDC, and 3-dehydro-L-gulonate-6-phosphate carboxy-lyase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.