3-deoxy-8-phosphooctulonate synthase

In enzymology, a 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + D-arabinose 5-phosphate + H₂O ${\displaystyle \rightleftharpoons }$ 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate

3-deoxy-8-phosphooctulonate synthase
Identifiers
EC no.	2.5.1.55
CAS no.	9026-96-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are phosphoenolpyruvate, D-arabinose 5-phosphate, and H₂O, whereas its two products are 2-dehydro-3-deoxy-D-octonate 8-phosphate and phosphate.

This enzyme participates in lipopolysaccharide biosynthesis.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming). Other names in common use include 2-dehydro-3-deoxy-D-octonate-8-phosphate, D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphooctonate aldolase, 2-keto-3-deoxy-8-phosphooctonic synthetase, 3-deoxy-D-manno-octulosonate-8-phosphate synthase, 3-deoxy-D-mannooctulosonate-8-phosphate synthetase, 3-deoxyoctulosonic 8-phosphate synthetase, KDOP synthase, and phospho-2-keto-3-deoxyoctonate aldolase.