3-Isopropylmalate dehydrogenase

3-Isopropylmalate dehydrogenase (EC 1.1.1.85) is an enzyme that is a part of the isopropylmalate dehydrogenase family, which catalyzes the chemical reactions:^[1][2][3][4]

(2R,3S)-3-isopropylmalate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 4-methyl-2-oxopentanoate + CO₂ + NADH

(2R,3S)-3-isopropylmalate + NAD⁺ ${\displaystyle \rightleftharpoons }$ (2S)-2-isopropyl-3-oxosuccinate + H⁺ + NADH

(2S)-2-isopropyl-3-oxosuccinate + H⁺ ${\displaystyle \rightleftharpoons }$ 4-methyl-2-oxopentanoate + CO₂

3-Isopropylmalate dehydrogenase
Identifiers
EC no.	1.1.1.85
CAS no.	9030-97-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
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