3alpha-hydroxycholanate dehydrogenase

In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC 1.1.1.52) is an enzyme that catalyzes the chemical reaction

Lithocholic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

Dehydrolithocholic acid

+ NADH

 

3-alpha-hydroxycholanate dehydrogenase
Identifiers
EC no.	1.1.1.52
CAS no.	9028-57-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are the bile acid lithocholic acid and nicotinamide adenine dinucleotide (NAD⁺). Its products are dehydrolithocholic acid, NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD⁺ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1IHI.