3alpha-hydroxycholanate dehydrogenase

In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC 1.1.1.52) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxy-5beta-cholanate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 3-oxo-5beta-cholanate + NADH + H⁺

3-alpha-hydroxycholanate dehydrogenase
Identifiers
EC no.	1.1.1.52
CAS no.	9028-57-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-cholanate and NAD⁺, whereas its 3 products are 3-oxo-5beta-cholanate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD⁺ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1IHI.