3alpha-hydroxysteroid dehydrogenase (A-specific)

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical reaction

androsterone + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ 5alpha-androstane-3,17-dione + NAD(P)H + H⁺

3-alpha-hydroxysteroid dehydrogenase (A-specific)
Identifiers
EC no.	1.1.1.213
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are androsterone, NAD⁺, and NADP⁺, whereas its 4 products are 5alpha-androstane-3,17-dione, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)⁺ oxidoreductase (A-specific).

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1J96, 1LWI, 1S1P, 1S1R, 1S2A, 1S2C, 1XJB, 2F38, 2FGB, 2HDJ, and 2IPJ.