4-AcO-MET

4-AcO-MET, also known as 4-acetoxy-N-methyl-N-ethyltryptamine or metacetin, is a psychedelic drug of the tryptamine family. It is the acetate ester of 4-HO-MET, and a homologue of 4-AcO-DMT. It is a novel compound with very little history of human use.^[2] It is sometimes sold as a research chemical by online retailers.

4-AcO-MET

Clinical data
Other names	4-Acetoxy-MET; 4-Acetoxy-N-methyl-N-ethyltryptamine; Metacetin
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1]
Identifiers
IUPAC name [3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate
CAS Number	1445751-40-5
PubChem CID	71308138
ChemSpider	26633897
UNII	PCJ17NV1P0
CompTox Dashboard (EPA)	DTXSID301029955
Chemical and physical data
Formula	C15H20N2O2
Molar mass	260.337 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(C)CCc1c[nH]c2c1c(ccc2)OC(=O)C
InChI InChI=1S/C15H20N2O2/c1-4-17(3)9-8-12-10-16-13-6-5-7-14(15(12)13)19-11(2)18/h5-7,10,16H,4,8-9H2,1-3H3 Key:OMDKHOOGGJRLLX-UHFFFAOYSA-N

Pharmacology

Due to its similarity to the psilocin prodrug 4-AcO-DMT, which is deacetylated to form psilocin in vivo,^[3][4] it is expected that 4-AcO-MET is also quickly hydrolyzed into 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.

The pharmacology of 4-AcO-MET has been studied.^[5][6]

Society and culture

Legal status

Switzerland

In Switzerland, 4-Acetoxy-MET is a controlled substance under Verzeichnis E.^[7]

United Kingdom

In the United Kingdom, 4-AcO-MET is a Class A drug in the United Kingdom because it is an ester of the drug 4-HO-MET, which is a Class A drug under the tryptamine catch-all clause.^[8]

United States

In the United States, 4-Acetoxy-MET is not scheduled. It may be considered an analogue of psilocin, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical purposes could be considered a crime under the Federal Analogue Act.^[9]