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4-HO-αMT
Chemical compound From Wikipedia, the free encyclopedia
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4-Hydroxy-α-methyltryptamine (4-HO-αMT; developmental code name MP-14) is a psychedelic drug of the tryptamine and α-alkyltryptamine families.[2][3][4][5] It is a close structural analogue of α-methyltryptamine (αMT) and produces similar effects to it, but with exacerbated side effects similarly to 5-MeO-αMT.[2][3][6]
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Use and effects
4-HO-AMT was assessed in clinical studies and was reported by Murphree and Bircher, based on unpublished observations by these researchers, to be psychedelic at oral doses of 15 to 20 mg and to have marked visual effects.[2][3][6][7] Side effects have included abdominal pain, diarrhea, dizziness, headache, depressed feelings, dilated pupils, increased heart rate, increased blood pressure, urinary retention, and urinary hesitancy.[2][3][6] It has been reported to have strongly increased effects on smooth muscle relative to AMT, which is implicated in the urinary difficulty.[2][3]
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Pharmacology
4-HO-AMT has been found to produce electroencephalogram (EEG) changes in animals.[5][8]
4-Hydroxylation of dimethyltryptamine (DMT) into the related compound psilocin (4-HO-DMT) has been found to abolish its serotonin release induction in human embryonic kidney 293 (HEK293) stably transfected with the serotonin transporter (SERT) in vitro.[9]
History
4-HO-AMT was first described in the scientific literature by 1963.[5][8][2]
See also
References
External links
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