4-Hydroxycyclohexanecarboxylate dehydrogenase

In enzymology, a 4-hydroxycyclohexanecarboxylate dehydrogenase (EC 1.1.1.226) is an enzyme that catalyzes the chemical reaction

trans-4-hydroxycyclohexanecarboxylate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 4-oxocyclohexanecarboxylate + NADH + H⁺

4-hydroxycyclohexanecarboxylate dehydrogenase
Identifiers
EC no.	1.1.1.226
CAS no.	67272-36-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are trans-4-hydroxycyclohexanecarboxylate and NAD⁺, whereas its 3 products are 4-oxocyclohexanecarboxylate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is trans-4-hydroxycyclohexanecarboxylate:NAD⁺ 4-oxidoreductase. This enzyme is also called trans-4-hydroxycyclohexanecarboxylate dehydrogenase.