Androst-4-ene-3,17-dione monooxygenase

In enzymology, an androst-4-ene-3,17-dione monooxygenase (EC 1.14.99.12) is an enzyme that catalyzes the chemical reaction

androst-4-ene-3,17-dione + AH₂ + O₂ ${\displaystyle \rightleftharpoons }$ 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H₂O

androst-4-ene-3,17-dione monooxygenase
Identifiers
EC no.	1.14.99.12
CAS no.	37256-74-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are androst-4-ene-3,17-dione, an electron acceptor AH₂, and O₂, whereas its 3 products are 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone, the reduction product A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidorcockeductase (13-hydroxylating, lactonizing). Other names in common use include androstene-3,17-dione hydroxylase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstenedione monooxygenase, and 4-androstene-3,17-dione monooxygenase. This enzyme participates in androgen and estrogen metabolism.