4-chlorobenzoate—CoA ligase

In enzymology, a 4-chlorobenzoate—CoA ligase (EC 6.2.1.33) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoate + CoA + ATP ${\displaystyle \rightleftharpoons }$ 4-chlorobenzoyl-CoA + AMP + diphosphate

4-Chlorobenzoate—CoA ligase
Identifiers
EC no.	6.2.1.33
CAS no.	141583-20-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are 4-chlorobenzoate, CoA, and ATP, whereas its 3 products are 4-chlorobenzoyl-CoA, AMP, and diphosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-chlorobenzoate:CoA ligase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, magnesium.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5D and 1T5H.