4-hydroxyphenylpyruvate oxidase

In enzymology, a 4-hydroxyphenylpyruvate oxidase (EC 1.2.3.13) is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylpyruvate + 1/2 O₂ ${\displaystyle \rightleftharpoons }$ 4-hydroxyphenylacetate + CO₂

4-hydroxyphenylpyruvate oxidase
Identifiers
EC no.	1.2.3.13
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 4-hydroxyphenylpyruvate and O₂, whereas its two products are 4-hydroxyphenylacetate and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating). This enzyme participates in tyrosine metabolism.