4-trimethylammoniobutyraldehyde dehydrogenase

In enzymology, a 4-trimethylammoniobutyraldehyde dehydrogenase (EC 1.2.1.47) is an enzyme that catalyzes the chemical reaction

4-trimethylammoniobutanal + NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ 4-trimethylammoniobutanoate + NADH + 2 H⁺

4-trimethylammoniobutyraldehyde dehydrogenase
Identifiers
EC no.	1.2.1.47
CAS no.	73361-01-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are 4-trimethylammoniobutanal, NAD⁺, and H₂O, whereas its 3 products are 4-trimethylammoniobutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-trimethylammoniobutanal:NAD+ 1-oxidoreductase. Other names in common use include 4-trimethylaminobutyraldehyde dehydrogenase, and 4-N-trimethylaminobutyraldehyde dehydrogenase. This enzyme participates in lysine degradation and carnitine biosynthesis.

See also

• Carnitine biosynthesis
• γ-Butyrobetaine hydroxylase
• N^ε-Trimethyllysine hydroxylase