5-carboxymethyl-2-hydroxymuconate Delta-isomerase

In enzymology, a 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) is an enzyme that catalyzes the chemical reaction

5-carboxymethyl-2-hydroxymuconate ${\displaystyle \rightleftharpoons }$ 5-carboxy-2-oxohept-3-enedioate

5-carboxymethyl-2-hydroxymuconate delta-isomerase
Identifiers
EC no.	5.3.3.10
CAS no.	79079-05-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Hence, this enzyme has one substrate, 5-carboxymethyl-2-hydroxymuconate, and one product, 5-carboxy-2-oxohept-3-enedioate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is 5-carboxymethyl-2-hydroxymuconate Delta2,Delta4-2-oxo,Delta3-isomerase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1GTT, 1I7O, 1WZO, and 2DFU.