5-dehydro-4-deoxyglucarate dehydratase

The enzyme 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) catalyzes the chemical reaction

5-dehydro-4-deoxy-D-glucarate ${\displaystyle \rightleftharpoons }$ 2,5-dioxopentanoate + H₂O + CO₂

5-dehydro-4-deoxyglucarate dehydratase
Identifiers
EC no.	4.2.1.41
CAS no.	37290-77-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Enzyme class

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating 2,5-dioxopentanoate-forming). Other names in common use include 5-keto-4-deoxy-glucarate dehydratase, deoxyketoglucarate dehydratase, D-4-deoxy-5-ketoglucarate hydro-lyase, and 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating). This enzyme participates in ascorbate and aldarate metabolism.