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5-Hydroxycytosine

Chemical compound From Wikipedia, the free encyclopedia

5-Hydroxycytosine
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5-Hydroxycytosine is an oxidized form of cytosine that is associated with an increased frequency of C to T transition mutations, with some C to G transversions.[1] It does not distort the DNA molecule and is readily bypassed by replicative DNA polymerases.[2]

Quick Facts Names, Identifiers ...

It has been shown in vitro to miscode for adenine.

5-hydroxycytosine is imperative for parallel DNA triplex formation, explaining why parallel triplexes form only at pH 6 and below.

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