6'-Guanidinonaltrindole

6′-Guanidinonaltrindole
Names
	IUPAC name N-[17-(Cyclopropylmethyl)-3,14-dihydroxy-1′H-4,5α-epoxyindolo[2′,3′:6,7]morphinan-6′-yl]guanidine
	Systematic IUPAC name N-[(4bS,8R,8aS,14bR)-7-(Cyclopropylmethyl)-1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-b]pyrido[4,3-c]carbazol-12-yl]guanidine
Identifiers
CAS Number	350693-06-0;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL610279;
ChemSpider	24674392;
PubChem CID	9912633;
	InChI InChI=1S/C27H29N5O3/c28-25(29)30-15-4-5-16-17-11-27(34)20-9-14-3-6-19(33)23-21(14)26(27,7-8-32(20)12-13-1-2-13)24(35-23)22(17)31-18(16)10-15/h3-6,10,13,20,24,31,33-34H,1-2,7-9,11-12H2,(H4,28,29,30)/t20-,24+,26+,27-/m1/s1 Key: XDKOGAAFSBGLBO-GYHUNEDQSA-N;
	SMILES c1cc2c(cc1NC(=N)N)[nH]c3c2CC4(C5Cc6ccc(c7c6C4(C3O7)CCN5CC8CC8)O)O;
Properties
Chemical formula	C27H29N5O3
Molar mass	471.561 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

6′-Guanidinonaltrindole (6′-GNTI) is a κ–δ-opioid receptor selective ligand used in scientific research.^[1]

Quick facts Names, Identifiers ...

With 6′-GNTI, evidence was provided for the first time that receptor oligomerization plays functional role in living organisms.^[2]

6′-GNTI is an extremely biased agonist of the κ-opioid receptor.^[1] It is a potent partial agonist of the G protein pathway but does not recruit the β-arrestin pathway.^[1] Due to its functional selectivity for the G protein pathway, 6′-GNTI functions as an antagonist of nonbiased KOR agonists on the β-arrestin pathway.^[1] It is thought that 6′-GTNI may be able to produce analgesia without dysphoria and with a lower incidence of tolerance.^[1]

See also