6-Hydroxy-3-succinoylpyridine 3-monooxygenase

6-hydroxy-3-succinoylpyridine 3-monooxygenase (EC 1.14.13.163, 6-hydroxy-3-succinoylpyridine hydroxylase, hspA (gene), hspB (gene)) is an enzyme with systematic name 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing).^[1][2] This enzyme catalyses the following chemical reaction

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD⁺ + H₂O

6-hydroxy-3-succinoylpyridine 3-monooxygenase
Identifiers
EC no.	1.14.13.163
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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6-hydroxy-3-succinoylpyridine 3-monooxygenase catalyses a reaction in the nicotine degradation pathway of Pseudomonas species.