A-412997

A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D₄ subtype, with significantly improved selectivity over older D₄-preferring compounds such as PD-168,077 and CP-226,269.^[1] In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability.^[2][3] Also unlike other dopamine agonists, selective D₄ agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.^[4]

A-412997

Identifiers
IUPAC name N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide
CAS Number	630116-49-3 1347744-96-0 (di‑hydrochloride)
PubChem CID	10425450
IUPHAR/BPS	3301
ChemSpider	8600878 Y
UNII	RWL9H93ARB
ChEMBL	ChEMBL375596 Y
CompTox Dashboard (EPA)	DTXSID70212234
Chemical and physical data
Formula	C19H23N3O
Molar mass	309.413 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(NC(CN2CCC(C3=CC=CC=N3)CC2)=O)=CC=C1
InChI InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23) Y Key:JFCDMGGMCUKHST-UHFFFAOYSA-N Y
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