AAAP family

The Amino Acid/Auxin Permease (AAAP) Family (TC# 2.A.18) is a family of secondary carrier proteins, a member of the APC Superfamily that includes hundreds of proteins from plants, animals, fungi and lower eukaryotes. Six AAAPs in A. thaliana are well characterized and transport neutral and charged amino acids with varying specificities and affinities.^[1][2]

Amino Acid/Auxin Permease Family
Identifiers
Symbol	AAAP
Pfam	PF01490
Pfam clan	CL0062
InterPro	IPR013057
TCDB	2.A.18
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Function

Among animal AAAP family members are numerous growth regulating System A and System N isoforms, each exhibiting distinctive tissue and subcellular localizations. The different isoforms also exhibit different relative affinities for the amino acid substrates. Some catalyze H⁺ antiport and can function bidirectionally. Since Systems A are electrogenic which Systems N are not, the amino acid:cation stoichiometries may differ.^[2][3][4][5]