ACV synthetase

ACV synthetase (ACVS, L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synthetase, N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase, EC 6.3.2.26) is an enzyme that catalyzes the chemical reaction

3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H₂O ${\displaystyle \rightleftharpoons }$ 3 AMP + 3 PP_i + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

N-(5-Amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Identifiers
EC no.	6.3.2.26
CAS no.	57219-73-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The five substrates of this enzyme are ATP, L-2-aminohexanedioate, L-cysteine, L-valine, and H₂O, whereas its three products are AMP, diphosphate, and N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine.

ACVS is an example of a nonribosomal peptide synthetase (NRPS). It participates in penicillin and cephalosporin biosyntheses.